Safety First
In sloping patent glazing situations, it is a requirement to install glass which will either tend to stay in place if it is cracked (laminated safety glass fall into this category) or to fracture into relatively harmless pieces (toughened safety glass falls into this category) which are less likely to cause serious injury, if they fall, rather than sharp shards of annealed glass.
BS 5516: 2004 Code of practice for vertical and sloping patent glazing, CWCT TN112 and BS6262:2018 are the regulatory and or guidance documents which give recommendations about the type of glass to use in roofs.
For single glazing, laminated or toughened glass is recommended by BS 5516, while double glazed units should have safety glass as the lower pane.
With regard to toughened glass, BS 5516 suggests that, if the lower pane of a double glazed unit is toughened, then the upper pane should also be a safety glass.